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Small-molecule binding-site discovery using silyl ether-enabled chemoproteomics

by PaulHoule · 3 minutes ago

1|www.nature.com|0 comments

The Difference Between Development and Engineering

by tacoda · 4 minutes ago

1|tacoda.medium.com|0 comments

How to Save Tokens When Coding with AI Agents: Subtitle Yadda Yadda

by zhenyi · 6 minutes ago

2|zhenyi.gibber.blog|1 comments

Things to lighten dependency on web apps

by initramfs · 7 minutes ago

1|inavoyage.blogspot.com|0 comments

Show HN: OpenPayphone – open-source guts for a 1996 coin payphone (Pi and SIP)

by mcintyem · 8 minutes ago

2|github.com|0 comments

The week I lost the plot at a startup where the tools worked as advertised

by nilaloeber · 10 minutes ago

1|nlkw.de|0 comments

Thinking Like a Harness Engineer

by killiancarroll · 10 minutes ago

1|killianc.com|0 comments

Russia's new 'Starlink‑Style' Rassvet fleet loses first satellite after weeks

by pinewurst · 12 minutes ago

3|www.tomshardware.com|0 comments

US universities boost market risk as financial pressures mount

by JumpCrisscross · 13 minutes ago

2|www.ft.com|0 comments

How to convert bytes to grams (2023)

by bookofjoe · 13 minutes ago

1|bryanhu.com|0 comments

Progressive Lenses Elevate Fall Risk in Older Adults (2025)

by walterbell · 13 minutes ago

1|www.optometryadvisor.com|0 comments

WSL vs Wine

by freeopinion · 17 minutes ago

A lifetime ago some Linux advocates worried that the advent of Wine would reduce the incentive to produce native Linux apps.

Today some people believe that the heroics of Valve and others have finally made it possible to use a Linux desktop for daily gaming, including playing Windows games.

I wonder why WSL hasn't made the scales tip the other direction. Today's devs could build AutoCAD for GTK and have it run in Windows and Linux. Photoshop for KDE could run in Linux and Windows.

So what is so compelling about Windows native apps today that keeps Big Software locked in? What does Windows offer these devs that is missing in Linux?

1||1 comments

Halide Mark III

by tosh · 18 minutes ago

1|www.lux.camera|0 comments

Flu Vaccines Should Not Be This Hard

by paulpauper · 19 minutes ago

2|www.theatlantic.com|0 comments

AI #171: False Flag

by paulpauper · 20 minutes ago

1|thezvi.substack.com|0 comments

Musk's SpaceX IPO Narrative Is a Whole New Level of Bullshit

by doener · 20 minutes ago

7|text.tchncs.de|1 comments

Show Show HN: PrivatePulse – Value startup equity using secondary market data

by gbnt · 21 minutes ago

1|www.privatepulse.online|0 comments

Plasticity and language in the anaesthetized human hippocampus

by bookofjoe · 21 minutes ago

1|www.nature.com|0 comments

Show HN: Context Mode Insight – observability layer for AI coding agents

by mksglu · 21 minutes ago

1|context-mode.com|0 comments

French billionaire seeks law change to leave fortune to charity

by paulpauper · 22 minutes ago

1|www.msn.com|1 comments